Drug deaths draw the most notice, but more addicted people live than die. For them and their families, life can be a relentless cycle of worry, hope and chaos.
New Hampshire is relatively prosperous, with low crime and unemployment. But the state is short on treatment centers, and drugs are readily available in nearby Massachusetts.
An experimental court in Buffalo steers opioid users into treatment instead of jail. The judge uses his own recovery story as an example.
Decimated by addiction, its heritage at risk, the Cherokee Nation is trying to sue pharmacies and distributors. But it may be blocked from doing so.
Andrew gave his mother, Regina Hensley, a reason to live. We follow the pair as she fights a history of addiction and he fights an aggressive form of cancer.
Some celebrities have promised to enroll in treatment following accusations of sexual impropriety. But experts say there is no proven treatment.